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Evidence

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Head-to-head studies Admelog vs Humalog

Similar PK/PD profile chart

Similar PK/PD profile1

PK/PD profiles in the biosimilar, Admelog, were similar to the EU-approved Humalog in adult males with Type 1 diabetes1

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Similar mean HbA1C reduction2,3

Similar mean HbA1C reduction from baseline to Week 26 in Admelog and Humalog groups, in both Type 1 and Type 2 diabetes2,3

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Similar mean HbA1c reduction chart

Type 1 diabetes and Type 2 diabetes chart

Similar long-term safety and tolerability profiles2,3

Similar rates of patients with at least one hypoglycaemic event, regardless of the category, was observed in both Admelog and Humalog groups in Type 1 and Type 2 diabetes2,3

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Abbreviations:
CI, confidence interval; EU, European Union; GIR, glucose infusion rate; HbA1c, glycated haemoglobin; INS, plasma insulin lispro concentration; PD, pharmacodynamic; PK, pharmacokinetic; T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus; UK, United Kingdom.

References:

  1. Kapitza C, et al. Diabetes Obes Metab. 2017;19(5):622–7
  2. Garg SK, et al. Diabetes Technol Ther. 2017;19(9):516–26
  3. Derwahl K, et al. Diabetes Technol Ther. 2018;20(1):1–10
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